Recent advances in PET radioligands for imaging of cerebral nicotinic acetylcholine receptors

VernacularTitle:神经型烟碱乙酰胆碱受体PET显像放射性配体研究进展
Author: Yexiong MO ; Yafu YIN ; Yaming LI
Publication Type:Journal Article
Keywords: Ligands; Receptors,cholinergic; Nicotine; Tomography,emission-computed; Trends
From: Chinese Journal of Nuclear Medicine and Molecular Imaging 2013;33(6):510-514
CountryChina
Language:Chinese
Abstract: There exist many studies on the radioligands for imaging of nicotinic acetylcholine receptors (nAChRs) in the human brain and the most common one is the radioligand binding to α4β2-nAChRs,the main subtype of cerebral nAChRs.There are few data published in the literature on the radioligands for the imaging of α7-nAChRs,another important subtype of cerebral nAChRs.This review summarizes recent work on PET radioligands for the imaging of cerebral nAChRs.