Progress in diagnosis and treatment of radioactive iodine-refractory differentiated thyroid carcinomas
10.3760/cma.j.issn.2095-2848.2013.06.030
- VernacularTitle:难治性分化型甲状腺癌131Ⅰ诊治进展
- Author:
Dan ZHAO
;
Jun LIANG
;
Yansong LIN
- Publication Type:Journal Article
- Keywords:
Thyroid neoplasms;
Radiotherapy;
Iodine radioisotope;
Trends
- From:
Chinese Journal of Nuclear Medicine and Molecular Imaging
2013;33(6):505-509
- CountryChina
- Language:Chinese
-
Abstract:
During 131Ⅰ therapy or the natural course of DTC,2％ to 5％ of them will gradually no longer be sensitive to 131Ⅰ therapy and lead to radioactive iodine-refractory DTC (RAIR-DTC).Recent studies found that alterations of critical molecular targets in main signal transduction pathways could decrease the iodine-trapping function of thyroid carcinoma,such as BRAFV600E mutation,followed by negative 131 Ⅰ-whole body scan (WBS) and discounted efficacy.This article reviews novel diagnostic and therapeutic modalities for RAIR-DTC.
