Comparative study of semi-quantitative value based on different reference point in diagnosis of pulmonary lesions with 18F-FDG coincidence imaging
10.3760/cma.j.issn.2095-2848.2013.06.007
- VernacularTitle:肺部病变18F-FDG符合线路显像不同参照点半定量值的对比研究
- Author:
Wu LU
;
Peng CHEN
;
Yong LIU
;
Changxiang SONG
;
Peng DU
- Publication Type:Journal Article
- Keywords:
Lung neoplasms;
Coincidence;
Tomography,emission-computed,single-photon;
Tomography,X-ray computed;
Deoxyglucose
- From:
Chinese Journal of Nuclear Medicine and Molecular Imaging
2013;33(6):430-432
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the optimal semi-quantitative uptake ratio for differentiation between benign and malignant lung lesions with 18F-FDG coincidence imaging.Methods One hundred and thirty-seven patients (89 males,48 females,age range:33-78 years) with lung diseases underwent 18 FFDG coincidence imaging.The maximum radioactivity counts of the lung lesions (T),normal chest wall soft tissues (NT1) and the contralateral lung tissue (NT2) were measured.The ratios of R1 (T/NT1) and R2(T/NT2) were calculated.The optimal threshold values of R1(cutoff)and R2(cutoff) were identified by ROC curve analysis.Using the optimal threshold,the sensitivity,specificity and accuracy were calculated.Results The optimal threshold values R1(cutoff)and R2(cutoff) were identified as 3.58 and 4.40.The sensitivity,specificity and accuracy were 90.0％(90/100),89.2％(33/37),89.8％(123/137) according to R1(cutoff) and 90.0％ (90/100),78.4％(29/37),86.9％(119/137) according to R2(cutoff) Conclusion Based on which the chest wall soft tissue is taken as a reference point,the optimal threshold value of T/NT1 is 3.58 in differentiation between benign and malignant lung lesions with 18F-FDG coincidence imaging.
