A preliminary clinical study on the assessment of liver fibrosis by elastography point quantification technique with multivariate regression analysis
10.3760/cma.j.issn.1004-4477.2013.12.009
- VernacularTitle:剪切波组织定量技术评估肝弹性硬度的多因素回归分析:初步临床研究
- Author:
Hong DING
;
Jiaojiao MA
;
Wenping WANG
;
Feng MAO
;
Chen XU
;
Beijian HUANG
- Publication Type:Journal Article
- Keywords:
Ultrasonography;
Liver cirrhosis;
Elasticity;
Elastography point quantification
- From:
Chinese Journal of Ultrasonography
2013;22(12):1041-1044
- CountryChina
- Language:Chinese
-
Abstract:
Objective To preliminarily evaluate the feasibility of elastography point quantification (ElastPQ) technology in the determination of liver stiffness as well as its impact factors.Methods Amount to 235 patients with liver neoplasms underwent liver stiffness measurement in the right lobe of liver using an ultrasound scanner (iU Elite,Philips).ElastPQ values were obtained and compared with the liver fibrosis stage (S),the grade of necroinflammatory activity (G) and steatosis assessed histologically as well as gender and age.The factors related to ElastPQ values were explored by stepwise regression in multiple linear regression analysis and the regression equation was established.Results In the multiple linear regression model of ElastPQ values,liver fibrosis and necroinflammatory activity were associated with ElastPQ (P ＜ 0.05) while other factors including age,gender and hepatic steatosis had no effect on ElastPQ statistically (P ＞0.05).The equation of linear regression was ElastPQ =1.205S + 1.075G + 4.537.Conclusions ElastPQ technique is a reliably noninvasive tool in the liver stiffness measurement.Liver fibrosis and necroinflammatory activity are the main factors affecting liver stiffness measured by ElastPQ.
