Correlation between serum 25-hydroxyvitamin D level and gestational diabetes mellitus
10.3760/cma.j.issn.1674-635X.2013.06.007
- VernacularTitle:血清25-羟维生素D水平与妊娠糖尿病的相关性
- Author:
Jianping YAO
;
Shuying ZHENG
- Publication Type:Journal Article
- Keywords:
Gestational diabetes mellitus;
25-Hydroxyvitamin D;
High sensitive C-reactive protein;
Insulin resistance
- From:
Chinese Journal of Clinical Nutrition
2013;21(6):359-361
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the relationship between serum 25-hydroxyvitamin D level and gestational diabetes mellitus (GDM).Methods The fasting plasma glucose,fasting insulin,25-hydroxyvitamin D,and high sensitive C-reactive protein (hs-CRP) levels in the normal glucose tolerance group and gestational diabetes mellitus (GDM) group were measured.The homostasis model assessment insulin resistant (HOMA-IR) and homostasis model assessment β cell (HOMA-B) were calculated for assessing the insulin resistance and β-cell function.The relationship between 25-hydmxyvitamin D and hs-CRP,HOMA-IR,and HOMA-B were analyzed.Results The level of 25-hydroxyvitamin D in the GDM group [(2.16 ± 0.38) nmol/L] was significantly lower than that in the normal glucose tolerance group [(4.13 ±0.79) nmol/L](P =0.001).Serum 25-hydroxyvitamin D level was negatively correlated with hs-CRP (r =-0.448,P =0.002) and HOMA-IR (r =0.396,P =0.004),but was positively related with HOMA-B (r =0.495,P =0.001).Conclusions The serum 25-hydmxyvitamin D level remarkably decreases in GDM patients.Vitamin D deficiency may cause the functional damage of beta cell of islet,increase insulin resistance,and thus contribute to the development of GDM.
