The relationship between human glucocorticoid receptor and steroid-resistant nephrotic syndrome
10.3760/cma.j.issn.1673-4912.2013.06.031
- VernacularTitle:糖皮质激素受体与儿童激素耐药型肾病综合征研究进展
- Author:
Xiumin ZHANG
- Publication Type:Journal Article
- Keywords:
Nephrotic syndrome;
Steroid-resistant;
Glucocorticoid receptor;
Gene polymorphism;
Children
- From:
Chinese Pediatric Emergency Medicine
2013;20(6):647-650
- CountryChina
- Language:Chinese
-
Abstract:
Idiopathic nephrotic syndrome is a common pediatric kidney disease,and glucocorticoid is the first choice to deal with it.However,not all children are absolutely sensitive to it,about 10 to 20 percent are steroid-resistant.Researches have shown that human glucocorticoid receptor is associating with steroid-resistant.This article summarized the expression of glucocorticoid receptor and its gene polymorphism in steroid-resistant children.
