Sepsis and severe sepsis in PICU infant: analysis of risk factors and clinical feature
10.3760/cma.j.issn.1673-4912.2013.06.013
- VernacularTitle:PICU婴儿脓毒症及严重脓毒症临床特征及预后危险因素分析
- Author:
Biru LI
;
Kang AN
;
Qing CAO
;
Li ZHAO
;
Juan QIAN
;
Ying WANG
- Publication Type:Journal Article
- Keywords:
Sepsis;
Severe sepsis;
Prognosis;
Infant
- From:
Chinese Pediatric Emergency Medicine
2013;20(6):595-598
- CountryChina
- Language:Chinese
-
Abstract:
Objective To analyze the clinical characteristics of PICU infant with sepsis,severe sepsis,and to explore the impact of prognostic factors.Methods We conducted a retrospective study of 141 cases (from January 2006 to December 2011) who were diagnosed as sepsis and severe sepsis to identify the clinical characteristics.There were 14 variables of the PICU admission day which concluded gender,age,underlying diseases,sepsis severity,organ involvement,critical score,blood biochemistry (lactate,albumin,glucose),blood gas (base excess,bicarbonate,pH),shock,culture-positive.The death or discharge as the outcome factor.The data were analyzed with the Logistic regression model.Results One hundred and forty-one cases aged from 1 to 12 months,of which 72 cases were sepsis and 69 cases were severe sepsis,29 cases died with the mortality of 20.6％.In 29 death children,13 cases had underlying diseases.In children with sepsis and severe sepsis,the most common infection site was lung,accounting for 47.2％ (34/72) and 47.8％ (33/69) ;blood cultures were positive for 34 cases,accounting for 47.2％ (34/72) and 49.3％ (34/69).Variables in the univariate analysis those were significantly associated with death from sepsis were gender,underlying diseases,age,sepsis severity,shock,organ involvement,the number of critical illness score,blood lactate,base excess,bicarbonate and pH.In the Logistic regression model,the variables significantly associated with death were the severity of sepsis (OR =22.5,95 ％ CI =5.089,99.475),and the number of organ involvement (OR=3.305,95％CI=2.152,5.075).Conclusion The heavier sepsis severity and the more number of organ involvement are,the greater the risk of death will be.
