Abnormal glycometabolism in tumor cells
10.3760/cma.j.issn.1673-422X.2013.12.001
- VernacularTitle:肿瘤细胞的异常糖代谢
- Author:
Jie SUN
;
Xiangjun MENG
- Publication Type:Journal Article
- Keywords:
Glycolysis;
Mitochondria;
Neoplasms;
Hypoxia inducible factor
- From:
Journal of International Oncology
2013;40(12):883-885
- CountryChina
- Language:Chinese
-
Abstract:
The abnormal glucose metabolism of tumor cells is associated with a variety of mechanisms.Hypoxia inducible factor (HIF) is able to activate the glycolytic enzymes,which is conducive to getting energy through glycolysis.The dysfunction or the depletion in numbers of mitochondria can inhibit the oxidative phosphorylation pathway of glucose to some extent.The activation of oncogenes and the inactivation of tumor suppressor genes are also involved in the regulation of mitochondrial respiratory chain and glycolytic enzymes,thus affecting the process of glucose metabolism.Compared with normal cells,the synthesis of oxidative phosphorylation enzymes is inhibited in cancer cells.In addition,the abnormal glucose metabolism plays an important role in the growth,invasion and metastasis of tumor cells.
