Anti-tumor antibodies targeting CD47
10.3760/cma.j.issn.1673-422X.2013.11.005
- VernacularTitle:靶向CD47的抗肿瘤抗体研究进展
- Author:
Yushu WANG
;
Zhaoping ZHOU
;
Qingning SU
- Publication Type:Journal Article
- Keywords:
Neoplasms;
Antibodys;
Phagocytosis
- From:
Journal of International Oncology
2013;40(11):817-820
- CountryChina
- Language:Chinese
-
Abstract:
CD47 is a pluripotent molecule which plays a key role in the process of tumor immune escape.Blocking CD47 signal pathway can activate the macrophages to phagocytose tumor cells,which becomes a promising way for tumor immunotherapy.Monoclonal antibodies targeting CD47 have been the new focus during recent years.Present researches are carried out successfully,however it still needs more work before the clinical application of monoclonal antibodies targeting CD47.
