Contradictory effect and its mechanism of store-operated calcium channel in cancer cells
10.3760/cma.j.issn.1673-422X.2013.11.004
- VernacularTitle:钙库调控性钙通道在肿瘤细胞中的矛盾作用及其机制
- Author:
Peng GU
;
Dongrong YANG
- Publication Type:Journal Article
- Keywords:
Calcium channels;
Neoplasms;
Biological phenomena
- From:
Journal of International Oncology
2013;40(11):814-816
- CountryChina
- Language:Chinese
-
Abstract:
In most non-excitable cells,the store-operated calcium channel (SOCC) in the plasma membrane is the major calcium entry pathway.SOCC plays an important role in calcium signals that control many cancer cellular processes such as adhesion,secretion,movement,gene expression,proliferation,division and apoptosis.Stromal interaction molecule 1 (STIM1) and Orail are the two important parts of SOCC.So overexpression or suppression expression of STIM1/Orail can regulate SOCC activity and biological characteristics of cancer cells.However,SOCC plays a contradictory role in cancer cells,which can both promote tumor progression and inhibit tumor progression.SOCC is expected to become a new target for the treatment of tumors,but its complicated mechanism needs to consider both types of tumor cells and the external stimulators of tumor cells.
