Effects of ceramide-induced apoptosis on oncotherapy
10.3760/cma.j.issn.1673-422X.2013.11.003
- VernacularTitle:神经酰胺介导的凋亡效应在肿瘤治疗中的作用
- Author:
Qian WANG
;
Ping XIE
- Publication Type:Journal Article
- Keywords:
Ceramides;
Apoptosis;
Neoplasms;
Therapy
- From:
Journal of International Oncology
2013;40(11):811-814
- CountryChina
- Language:Chinese
-
Abstract:
Ceramide (Cer),as the center molecular of sphingolipids metabolism,functions as a bioactive mediator of different cellular processes,such as cell growth,differentiation,senescence and apoptosis,besides being structural component of cellular membrane.It can inhibit cell proliferation and promote cell apoptosis via multiple signal pathawys.Chemicals anti-cancer properties based on Cer metabolism that upregulate its level are confirmed in plenty of experimental researches,and parts of research productions are applied in anticancer clinic experiments.
