Expression regulation of Bnip3 and its relationship with tumors
10.3760/cma.j.issn.1673-422X.2013.11.002
- VernacularTitle:Bnip3基因的表达调控及其与肿瘤的关系
- Author:
Yan WANG
;
Zhiping LI
- Publication Type:Journal Article
- Keywords:
Gene expression regulation;
Neoplasms;
Bnip3 gene
- From:
Journal of International Oncology
2013;40(11):807-810
- CountryChina
- Language:Chinese
-
Abstract:
Bnip3,a kind of mitochondrion apoptosis gene,belongs to the Bcl-2 gene family and BH3-only subfamily.It is one of the downstream response factors of hypoxia inducible factor (HIF).Bnip3 can induce cell apoptosis and autophagy under the oxygen deficit condition.Many studies show that Bnip3 is closely related to the occurrence,development and treatment of tumors.Molecular targeting treatment aimed at Bnip3 combined with chemoradiotherapy has preferable application foreground in tumor therapy.
