CRD-BP and β-TrCP in colorectal cancer
10.3760/cma.j.issn.1673-422X.2013.12.016
- VernacularTitle:CRD-BP和β-TrCP在结直肠癌中的研究
- Author:
Li CHENG
;
Li CHENG
;
Dandan JIA
;
Wenjuan QI
;
Changjiang ZHOU
- Publication Type:Journal Article
- Keywords:
Colorectal neoplasms;
Signal transduction;
Coding region instability determinant-binding protein;
Beta-transducin repeats-containing protein
- From:
Journal of International Oncology
2013;40(12):930-932
- CountryChina
- Language:Chinese
-
Abstract:
Coding region instability determinant (CRD) is one of the influence factors of oncogene c-myc.Coding region instability determinant-binding protein (CRD-BP) can connect with CRD in order to protect CRD from nuclease attack,prevent rapid degradation of c-myc mRNA,and increase c-myc protein content.Beta-transducin repeats-containing protein (β-TrCP) can affect cell growth,differentiation,apoptosis and oncogenesis by regulating multiple signaling pathways and cell cycle.The overexpression of CRD-BP can upregulate the expression of β-TrCP and both of them play important roles in the tumorigenesis,progression,metastasis and invasion of colorectal cancer.
