NOD2 gene and primary hepatocellular carcinoma
10.3760/cma.j.issn.1673-422X.2013.12.015
- VernacularTitle:NOD2基因与原发性肝癌
- Author:
Ning LIANG
;
Lili QIAO
;
Jian XIE
;
Jiandong ZHANG
- Publication Type:Journal Article
- Keywords:
Polymorphism,single nucleotide;
Carcinoma,hepatocellular;
Nucleotide-binding oligomerization domain protein 2
- From:
Journal of International Oncology
2013;40(12):927-929
- CountryChina
- Language:Chinese
-
Abstract:
Nucleotide-binding oligomerization domain protein 2 (NOD2) involves in host immune responses to pathogens and regulates natural immunity and specific immunity by identifying the peptidoglycan of bacterial cell walls and cleavage product muramyl dipeptide.As a newly discovered intracellular pattern recognition receptor,NOD2 plays important roles in the development of primary hepatocellular carcinoma by gene mutate,inducing liver inflammatory reaction and activating relevant signaling pathways.
