EMT mediated cancer stemness and tumor
10.3760/cma.j.issn.1673-422X.2013.12.006
- VernacularTitle:上皮-间质转化及其干性作用与肿瘤
- Author:
Chunyan DENG
;
Xiaoqin TAN
;
Tao LI
;
Jianming HUANG
- Publication Type:Journal Article
- Keywords:
Cell transformation,neoplastic;
Neoplastic stem cells;
Twist transcription factor
- From:
Journal of International Oncology
2013;40(12):899-902
- CountryChina
- Language:Chinese
-
Abstract:
Epithelial-mesenchymal transition (EMT) is a major mechanism in tumor metastasis.As the key regulatory factor,Twist gene plays an important role in EMT,and it can be induced by radiotherapy,chemotherapy and a variety of cytokines.Researches show that tumor cells can get stem cell-like properties via EMT,which can lead to chemo-radiotherapy resistance,tumor angiogenesis and distant metastasis.EMT has a great influence on the prognosis of tumor,and it is expected to become an important target for tumor treatment.
