Y-box-binding protein 1 and epithelial-mesenchymal transition
10.3760/cma.j.issn.1673-422X.2013.12.005
- VernacularTitle:Y盒结合蛋白1与上皮-间质转化
- Author:
Xuebing YAN
;
Qingchao ZHU
;
Zhiming JIN
- Publication Type:Journal Article
- Keywords:
Y-box-binding protein 1;
Cell transformation,neoplastic;
Transcription factors;
Signal transduction
- From:
Journal of International Oncology
2013;40(12):896-899
- CountryChina
- Language:Chinese
-
Abstract:
In the process of epithelial-mesenchymal transition (EMT),cell-cell adherence is disrupted,apico-basal polarity is lost,the ability of anti-apoptosis,migration and invasion is acquired.Y-box-binding protein 1 (YB-1) is a member of the cold-shock protein superfamily,containing a structurally and functionally conserved cold shock domain.Studies indicate that YB-1 can promote the occurrence and development of tumors by regulating EMT.In the process of EMT mediated by YB-1,various transcription factors and signal pathways play important roles.
