Epithelial-mesenchymal transition and gastric cancer
10.3760/cma.j.issn.1673-422X.2013.12.014
- VernacularTitle:上皮-间质转化与胃癌
- Author:
Limin LIU
;
Jikun LI
- Publication Type:Journal Article
- Keywords:
Stomach neoplasms;
Signal transduction;
Neoplasm metastasis;
Epithelial-mesenchymal transition
- From:
Journal of International Oncology
2013;40(12):924-926
- CountryChina
- Language:Chinese
-
Abstract:
Epithelial-mesenchymal transition (EMT) is that cells undergo a switch from epithelial phenotype to mesenchymal phenotype.Recent researches show that EMT can affect the occurrence and development of gastric cancer through a variety of mechanisms and promote the migration and invasion of tumor cells.The process of EMT involves a number of signal transduction pathways,and is related to microRNAs,Helicobacter pylori,transcription factors and so on.EMT is expected to be a novel therapeutic target of gastric cancer.
