Roles of SIRT1 in tumorigenesis and tumor progression
10.3760/cma.j.issn.1673-422X.2013.12.007
- VernacularTitle:沉默信息调节因子1在肿瘤发生发展中的作用
- Author:
Deqiang FU
;
Wenyi WU
;
Liting ZHANG
- Publication Type:Journal Article
- Keywords:
Neoplasms;
Silent information regulator 1
- From:
Journal of International Oncology
2013;40(12):902-904
- CountryChina
- Language:Chinese
-
Abstract:
Silent information regulator 1 (SIRT1) is a kind of histone deacetylase which dependents on nicotinamide adenine dinucleotide.It is involved in the occurrence and development of tumors.Data show that SIRT1 is highly expressed in many tumors,such as gastric cancer,breast cancer,prostate cancer and so on.On the other hand,the expression of SIRT1 is lower in many other types of tumors,including glioblastomas,bladder cancer,ovarian cancer and so on.Therefore,the role of SIRT1 in tumor formation process is still uncertain and controversial.
