Clinical research on compensatory changes in the retained kidney after nephrectomy in living related donors
10.3760/cma.j.issn.0254-1785.2013.10.003
- VernacularTitle:亲属活体肾移植供者留存肾代偿性改变的临床研究
- Author:
Zheng CHEN
;
Jiali FANG
;
Lei ZHANG
;
Guanghui LI
;
Lu XU
;
Junjie MA
;
Guanghui PAN
- Publication Type:Journal Article
- Keywords:
Kidney transplantation;
Living donor;
Retained kidney;
Compensatory changes;
Hemodynamic index
- From:
Chinese Journal of Organ Transplantation
2013;34(10):587-590
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the compensatory changes in morphology,function,and hemodynamic indices of the retained kidney after nephrectomy among living related donors.Method The 170 living related kidney donors underwent assessments before surgery as well as at 1st and 12th month,postoperatively,including length,width,short diameter,glomerular filtration rate (GFR),effective renal plasma flow (ERPF),peak systolic blood flow velocity (Vsmax),resistance index (RI),as well as pulsatility indices (PI) of main renal artery (MRA),segmental renal artery (SRA),and interlobar renal artery (IRA).Results All subjects were followed up for 9 to 68 months,with no observed hypertension or kidney failure.The length,width,and short diameters of the retained kidney were increased significantly (P＜0.01) at 1st and 12th month postoperatively.The renal sizes at 1st month postoperation were similar to that at 12th month postoperation (P＞0.05).GFR and ERPF were increased significantly as compared with preoperative values (P＜0.01) with similar values at postoperative month 1 and 12 (P＞0.05).The Vsmax of MRA,SRA,and IRA in the retained kidney were increased significantly (P＜0.01),and the RI and PI were also increased as compared with the preoperative values (P＜0.05),albeit these indicators were similar at postoperative months 1 and 12 (P＞0.05).Conclusion For all subjects studied after unilateral nephrectomy in a living related donor,the diameter of the retained kidney as well as the GFR and ERPF showed compensatory increases.Various arterial hemodynamic parameters also showed compensatory changes.Under strict donor inclusion criteria,living related kidney donor procedures is safe.
