Effects of sucralfate and acid-suppressive drugs on preventing ventilator-associated pneumonia of mechanically ventilated patients: a meta-analysis
10.3760/cma.j.issn.0578-1426.2014.01.012
- VernacularTitle:硫糖铝和抑酸剂预防应激性溃疡对机械通气患者发生呼吸机相关性肺炎影响的Meta分析
- Author:
Hongli HE
;
Shuling HU
;
Qihong CHEN
;
Ling LIU
;
Yingzi HUANG
;
Yi YANG
;
Haibo QIU
- Publication Type:Journal Article
- Keywords:
Sucralfate;
Antacids;
Gastrointestinal hemorrhage;
Pneumonia,ventilator-associated;
Meta-analysis
- From:
Chinese Journal of Internal Medicine
2014;53(1):48-54
- CountryChina
- Language:Chinese
-
Abstract:
Objective To evaluate the effect of sucralfate and acid-suppressive drugs on preventing ventilator-associated pneumonia (VAP) in mechanically ventilated patients.Methods All randomized controlled trials (RCTs),which studied the effect of sucralfate and acid-suppressive drugs on the incidence of VAP in mechanically ventilated patients,were searched from PubMed,Embase and the Cochrane Library during January 1966 to March 2013 via manual and computer retrieval.All related data were extracted.Meta analysis was conducted using the statistical software RevMan 5.2 and the quality of the RCTs was strictly evaluated with the methods recommended by the Cochrane Collaboration.Results A total of 15 RCTs involving 1315 patients in the sucralfate group and 1568 patients in the acid-suppressive drug group were included in this study.The incidence of VAP was significantly reduced in the sucralfate group (RR =0.81,95％ CI 0.7-0.95,P =0.008),while no difference was found between the two groups in the incidence of stress-related gastrointestinal bleeding (RR =0.96,95％ CI 0.59-1.58,P =0.88).No statistical difference was found in the days on ventilator,duration of ICU stay and ICU mortality in the two groups (all P values ＞ 0.05).Conclusion In patients with mechanical ventilation,sucralfate could decrease the incidence of VAP,while has no such effect on the stress-related gastrointestinal bleeding,the days on ventilator,duration of ICU stay and ICU mortality.
