Roles of hypoxia and Notch1 in multiple myeloma
10.3760/cma.j.issn.1673-422X.2013.07.021
- VernacularTitle:乏氧及Notch1在多发性骨髓瘤中的作用
- Author:
Banban LI
;
Dongmei GUO
;
Qingliang TENG
- Publication Type:Journal Article
- Keywords:
Cell hypoxia;
Hypoxia-inducible factor 1,alpha subunit;
Multiple myeloma;
Receptor,Notch1
- From:
Journal of International Oncology
2013;40(7):542-546
- CountryChina
- Language:Chinese
-
Abstract:
Recently numerous studies have demonstrated that Notch signaling pathway plays a critical role in regulating cell proliferation and differentiation in hematopoietic microenvironment,which is associated with MM occurrence and the drug resistance.The latest researches show that there are close relations between hypoxia and Notch signaling pathway in tumor occurrence and progression.Exploring the interactions of microenvironment of hypoxia,HIF-1α and Notch signaling pathway will provide theoretical basis for MM targeted therapy.
