Roles of peroxisome proliferator activated receptor-γ in lung cancer
10.3760/cma.j.issn.1673-422X.2013.07.013
- VernacularTitle:过氧化物酶体增殖物激活受体γ在肺癌中的作用
- Author:
Fenglian FU
;
Yongxin JIANG
- Publication Type:Journal Article
- Keywords:
Lung neoplasms;
Peroxisome proliferator-activated receptors;
Ligands;
Neoplastic processes
- From:
Journal of International Oncology
2013;40(7):517-520
- CountryChina
- Language:Chinese
-
Abstract:
Peroxisome proliferator activated receptor-γ (PPARγ) is a member of the nuclear receptor superfamily of ligand-activated transcription factors that plays a critical role in regulating glucose and lipid homeostasis,and in the processes of tumor cell proliferation,differentiation,apoptosis,invasion and distant metastasis.Studies demonstrate that PPARγexpression is detected in human lung cancer tissues and numerous lung cancer cell lines.Activation of PPARγthrough its ligands impedes significantly a variety of tumor progression,including lung cancer.However,systemic activation of PPARγhas been reported to be protumorigenic in some in vitro systems and in vivo models.
