Effect of Gegen Qinlian Decoction on Rotavirus-inducing Diarrhea in Neonatal Mice
10.3969/j.issn.1005-5304.2013.07.014
- VernacularTitle:葛根芩连方抗Wa株轮状病毒的药效学研究
- Author:
Lijun SONG
;
Wenchang ZHAO
;
Xiaomei TAN
;
Mengmeng YANG
;
Jiabo LUO
- Publication Type:Journal Article
- Keywords:
Gegen Qinlian decoction;
rotavirus;
diarrhea;
mice
- From:
Chinese Journal of Information on Traditional Chinese Medicine
2013;(7):35-37
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the anti-rotavirus effect of Gegen Qinlian decoction on rotavirus (RV)-inducing diarrhea neonatal mice model, and provide evidences for pharmacological and pharmacodynamic studies. Methods Neonatal diarrhea mice model of Kunming family infected with RV-Wa was developed. Symptom, diarrhea ratio and severity level, histological changes of neonatal mice’s small intestine and lung was assessed after Gegen Qinlian decoction (0.78 g/kg) treatment. Results Diarrhea ratio, diarrhea severity level, histological changes of neonatal mice’s small intestine and lung were obviously decreased after Gegen Qinlian decoction (0.78 g/kg) treatment. Conclusion Gegen Qinlian decoction has anti-rotavirus effect on RV induced diarrhea.
