The effect of Shanzha Xiaozhi capsule on intima-media thickness and plaques score of carotid artery in patients with non-acute phase coronary heart disease
10.3969/j.issn.1008-9691.2013.05.003
- VernacularTitle:山楂消脂胶囊对非急性期冠心病患者颈动脉内-中膜厚度和斑块积分的影响
- Author:
Wenhui WANG
;
Huayun ZHAO
;
Weiqiang CHEN
;
Zixing LUO
;
Xiulan YU
;
Zhaohong LIU
;
Tong LIANG
- Publication Type:Journal Article
- Keywords:
Shanzha Xiaozhi capsule;
Non-acute phase coronary heart disease;
Carotid intima-media thickness;
Plaques score;
Phlegm stagnation syndrome;
Blood-stasis syndromee
- From:
Chinese Journal of Integrated Traditional and Western Medicine in Intensive and Critical Care
2013;(5):266-269
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the effect of Shanzha Xiaozhi capslue on intima-media thickness(IMT) and plaques score of carotid artery in patients with non-acute phase coronary heart disease and traditional Chinese medicine(TCM)syndrome of phlegm and blood stasis. Methods A prospective study was conducted to carry out a research on 102 patients with non-acute phase coronary heart disease and TCM syndrome of phlegm and blood stasis. They were randomly divided into two groups:a control group(50 cases)treated with conventional western medicine alone and a observation group(52 cases)which was treated by both conventional western medicine and Shanzha Xiaozhi capslue(the main TCM ingredients:Shanzha,Dahuang)0.7 g,3 times a day,the therapeutic course being 6 months in both groups. The cardiocerebral vascular incidences of the two groups were observed,in the mean time,the carotid artery IMT and plagues score were registered,the scores of phlegm stagnation syndrome and blood-stasis syndrome were measured,adverse reaction was observed and compared in both groups before and after treatment. Results After treatment,the occurrence of major adverse acute cardiovascular and cerebrovascular events in observation group were reduced significantly compared with those in the control group(5.77%vs. 20.00%,P<0.05). The IMT and plaques score of carotid artery and the scores of phlegm stagnation syndrome and blood-stasis syndrome were all decreased obviously compared to those before treatment,and the effect was more remarkable in the treatment group〔IMT of carotid artery(mm):0.80±0.13 vs. 0.95±0.12,the plaques score:1.35±0.65 vs. 1.75±0.88, phlegm syndrome score:20.98±6.42 vs. 35.55±9.22,blood-stasis syndrome score:23.23±5.12 vs. 28.95±6.38, P<0.05 or P<0.01〕. Abdominal pain appeared in 2 patients of observation group without other adverse reactions. Conclusion Shanzha Xiaozhi capsule can stabilize atherosclerotic plaque and reduce the occurrence of acute adverse cardiocerebral vascular events in patients with non-acute phase coronary heart disease and phlegm and blood stasis syndrome possibly by removing phlegm and blood stasis to decrease the IMT and plaques score of carotid artery.
