The relevance among serum CRP level,CRP gene C+1444T polymorphism and the risk with acute myocardial infarction *
10.3969/j.issn.1671-8348.2013.27.006
- VernacularTitle:CRP水平及基因多态性和急性心肌梗死发病风险的关系
- Author:
Haitao YANG
;
Guoping HE
;
Chuanping QI
;
Lianhong XU
;
Yichao QIAN
- Publication Type:Journal Article
- Keywords:
myocardial infarction;
C-reactive protein;
polymorphism,single nucleotide
- From:
Chongqing Medicine
2013;(27):3222-3224
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the relationship between serum C-reactive protein(CRP) level ,CRP gene C+1444T poly-morphism and the risk with Acute myocardial infarction (AMI) in Chinese Han population in Sunan region .Methods The CRP gene C+1444T polymorphism was genotyped by Polymerase reaction restriction-fragment length polymorphism (PCR-RFLP) and the serum CRP level was measured by enzyme linked immunosorbent assay (ELISA) between 227 patients with AMI(AMI group) and 161 control subjects .Results No differences were found in genotype distribution between AMI group and controls (CC 82 .38% ,CT 17 .62% ,TT 0% vs 86 .96% ,13 .04% ,0% )(P>0 .05) .The serum CRP level in AMI group was significantly higher than controls(P< 0 .01) .There was no differences in the serum level between any genotypes of the CRP gene C + 1444T (P<0 .05) .Conclusion The CRP gene C+1444T polymorphism is not associate with increased risk of AMI ,and it have no effect with the serum level in Chinese Han population in Sunan region .
