Analysis of cagA+ Helicobacter pylori infection and expression level of COX-2 in gastric tumor tissue
10.3969/j.issn.1671-8348.2013.26.003
- VernacularTitle:胃癌组织cagA阳性幽门螺杆菌感染与环氧化酶-2的关系
- Author:
Hongxia QI
;
Xiaohong LI
;
Ya YUAN
- Publication Type:Journal Article
- Keywords:
stomach neoplasms;
nelicobacter;
cyclooxygenase-2;
cagA
- From:
Chongqing Medicine
2013;(26):3087-3088
- CountryChina
- Language:Chinese
-
Abstract:
Objective To observe the cyclooxygenase-2(COX-2) expression of gastric tumor tissue ,and to study the relationship between cagA + Helicobacter pylori(Hp cagA+ ) infection and COX-2 .Methods 42 specimens of gastric cancer tissue (including gastric carcinoma ,paracancerous hyperplastic tissue and paracancerous normal gastric mucosa ) in our hospitals from January 2010 to August 2011 were collected and detected the Hp cagA expression by PCR .Results The COX-2 protein positive rate in the gas-tric tcancer tissue was significantly higher than that in the paracancerous hyperplastic tissue and normal gastric mucosa (P<0 .01) . Among 42 cases of gastric cancer specimens ,Hp cagA+ was in 25 cases ,Hp cagA - was in 17 cases .The COX-2 protein positive rate was 88 .0% (22/25) in the Hp cagA+ group and 35 .3% (6/17) in the Hp cagA - group .The COX-2 protein positive rate in the Hp cagA+ gastric tissue was significantly higher than that in the Hp cagA - gastric tissue(P<0 .01) .Conclusion Abnormal ex-pression of COX-2 exists in gastric tcancer tissue ,cagA+ Helicobacter pylori infection may promote the occurrence and development of gastric cancer by regulating the expression level of COX-2 .
