Influence of Butylphthalide Soft Capsules on hemodynamics in acute cerebral infarction

VernacularTitle:丁苯酞软胶囊对急性脑梗死血流动力学的影响
Author: Chunli YIN ; Yaowu WANG ; Liying WANG
Publication Type:Journal Article
Keywords: rain infarction; CT; Butylphthalide Soft Capsules; hemodynamic
From: Chongqing Medicine 2013;(26):3091-3093
CountryChina
Language:Chinese
Abstract: Objective To evaluate the effect of Butylphthalide Soft Capsules on cerebral hemodynamics in patients with acute cerebral infarction by 64 slice spiral CT perfusion(CTP) imaging .Methods The patients with acute cerebral hemisphere infarction within 6 h after the onset were selected and randomly divided into the experimental group and the control group .Conventional plain CT and CTP were performed in both groups .In addition to the routine treatment the experimental group was orally administrated Butylphthalide Soft Capsules 0 .2 g ,once per 6 h .The CTP examination was performed again after 12 h .Results The CTP exami-nation showed that the cerebral perfusion in experimental group was improved in the ischemic marginal region ,the cerebral blood flow(CBF) and cerebral blood volume(CBV) were increased compared with before treatment ,the mean transit time(MTT) and the time to peak( TTP) were shortened compared with the before treatment .Conclusion Butylphthalide Soft Capsules can significantly improve the CBV of ischemic penumbra region and brain ischemic hypoperfusion .