Study on changes and influence of humoral immunity in premature infants

VernacularTitle:早产儿体液免疫变化及影响因素研究
Author: Chunhong WANG ; Jianhe WEI ; Zhenkui LIU ; Peixia XIAO ; Yajing ZHANG ; Erwei YUAN
Publication Type:Journal Article
Keywords: infant,premature; immunity; complement C3; complement C4
From: Chongqing Medicine 2013;(26):3112-3114
CountryChina
Language:Chinese
Abstract: Objective To study changes of humoral immunity of the premature infants in different pathological conditions and detect the reason of the deficiency of humoral immunity in premature infants .Methods Two hundred and forty-six prematur were enrolled and 30 healthy neonates were selected as control group .The percentages of IgG ,IgA ,IgM and comp lement C3 ,C4 were detected by full automatic biochemical analyzer .Results The results showed that IgG ,IgM ,IgA ,C3 and C4 in the premature in-fants were lower than those in the normal term infants and there was a highly significant difference with the decrease of fetal age . IgG ,IgM ,IgA ,C3 and C4 of the group of the premature infants ranging from 32 to 36 weeks had reduced in different degree ,rela-tive to the groups of BW <2 000 g ,hypertension during pregnancy ,cesarean section(P<0 .05) .Conclusion The results showed that function of humoral immunity in the premature infants was depressed and low gestational age ,low birth weight ,cesarean sec-tion and hypertension during pregnancy may be the leading cause of the deficiency of humoral immunity .