Influence of multiple sedation of dexmedetomidine and midazolam on young rats′nervous injury and learning and memory ability after grow up
10.3969/j.issn.1671-8348.2013.25.006
- VernacularTitle:右美托咪啶与咪达唑仑对幼鼠神经细胞损伤及学习记忆功能的影响
- Author:
Ping BAI
;
Xiujian WU
;
Dong YAN
- Publication Type:Journal Article
- Keywords:
learning;
memory;
midazolam;
dexmedetomidine;
young
- From:
Chongqing Medicine
2013;(25):2966-2968
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the influence of multiple sadation of dexmedetomidine (Dex) and midazolam on young rats′nervous injury and the learning and memory ability after grow up .Methods 36 male SD rats were randomly allocated to 3 groups (n=12):control group(C) ,midazolam group (M ) and dexmedetomidine group(D) .The group C was given normal saline 0 .1 mL/kg by subcutaneous injection .The group M was subcutaneously injected by midazolam 2 .4 mg/kg ,0 .1 mL/kg .The group D was subcutaneously injected by dexmedetomidine 75 μg/kg ,0 .1 mL/kg .Each group received once injection for 3 d .Plasma S100β,NSE were measured at 6 h after medication .The rats′memory ability after grow up was assessed by the Morris water maze test .Results Compared with the group C ,the escape latency in the group M was extended and the times across the platform was decreased . The expressions of S100βand NSE in the group M were enhanced at 6 h after medication .There was no statistical difference be-tween the group C and D .The changes of various indexes in the group D had no significance .Conclusion Compared with midazo-lam ,using new type narcotic and sedative agent dexmedetomidine had little influence on the young rat nervous injury and the learn-ing and memory ability after grow up in rat .
