Balance between regulatory T cells and T helper 17 cells in peripheral blood of patients with serofast syphilis
10.3969/j.issn.1671-8348.2013.27.001
- VernacularTitle:梅毒血清固定患者外周血调节性T细胞／T h17细胞平衡的变化
- Author:
Haijing YANG
;
Fei WANG
;
Zhengbang DONG
;
Jingdong ZHANG
- Publication Type:Journal Article
- Keywords:
syphilis;
T-lymphocytes,regulatory;
Th17 cells
- From:
Chongqing Medicine
2013;(27):3209-3210
- CountryChina
- Language:Chinese
-
Abstract:
Objective To observe the change of the balance between regulatory T (Treg) cells and T helper 17(Th17) cells in peripheral blood of the patients with serofast syphilis .Methods From January 2010 to September 2012 ,28 patients with serofast syphilis in our department were selected into the observation group and 30 normal persons were selected into control group .Flow cytometry was used to measure the expression of Treg cells ,Th17 cells ,specific transcription factors Foxp3 and ROR-γ in the pe-ripheral blood .The comparative analysis was carried out .Results The proportion of Treg cells in the peripheral blood of the obser-vation group was (34 .02% ± 12 .31% ) ,which was higher than (21 .86% ± 8 .24% ) in the control group(P<0 .05) ,and the pro-portion of Th17 cells in the peripheral blood of the observation group was (3 .08% ± 2 .17% ) ,which was lower than (9 .13% ± 1 .96% ) in the control group(P<0 .01);the expression level of Foxp3 of CD4+ T cells was (2946 .35 ± 995 .63) in the observation group ,which was higher than (2468 .74 ± 869 .63) in the control group(P< 0 .05),and the expression level of ROR-γwas (1438 .29 ± 659 .31) ,which was lower than(1831 .25 ± 426 .37) in the control group(P<0 .05) .All above differences had signifi-cantly statistical significance .Conclusion The Treg/Th17 cell balance is abnormal in peripheral blood of the patients with serofast syphilis .This cellular immunity suppression of human body may be the reason leading to serofast syphilis .
