Expression and significance of FoxP3 in non-keratinizing squamous cell carcinoma of nasopharynx *
10.3969/j.issn.1671-8348.2013.27.026
- VernacularTitle:叉头蛋白3在鼻咽非角化性鳞状细胞癌组织中的表达及意义
- Author:
Zhixing ZHANG
;
Hua XU
- Publication Type:Journal Article
- Keywords:
nasopharyngeal neoplasms;
mucosa with chronic inflammation;
regulatory T cell;
FoxP3;
CD8+ T lymphocyte
- From:
Chongqing Medicine
2013;(27):3272-3274
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the expression of FoxP3 in nasopharyngeal non-keratinizing squamous cell carcinoma and the significance of regulationary T (Treg) cell in the occurrence and development of nasopharyngeal carcinoma .Methods The im-munohistochemistry staining method(SP) was used to detect the expression of FoxP3 in 57 cases of nasopharyngeal non-keratiniz-ing squamous cell carcinoma and 22 cases of nasopharyngeal mucosa with chronic inflammation ,and the expression of CD8 in naso-pharyngeal carcinoma .Results The number of Treg cell with positive FoxP3 in the nasopharyngeal carcinoma group was 105 .05 ± 52 .22 ,which was significantly higher than 6 .35 ± 6 .06 in the nasopharyngeal mucosa with chronic inflammation ,the difference be-tween them showed statistical significance(P<0 .05) .The number of T cells with positive FoxP3 was relevant to gender and the differentiation degree of carcinoma(P<0 .05) .Conclusion The proliferation of Treg cells with positive FoxP3 can inhibit the anti-tumor immunologic function of the patients with nasopharyngeal non-keratinizing squamous cell carcinoma and provide the favor-able environment for the immunologic escape of tumor cells .
