Genetic association of complement factor B gene polymorphisms with susceptibility and prognosis of IgA nephropathy
10.3760/cma.j.issn.1001-7097.2013.07.002
- VernacularTitle:补体B因子基因遗传多态性与IgA肾病发病和预后的关联性
- Author:
Yaling ZHAI
;
Li ZHU
;
Hong ZHANG
- Publication Type:Journal Article
- Keywords:
IgA Nephropathy;
Factor B,complement;
Single nucleotide polymorphisms
- From:
Chinese Journal of Nephrology
2013;29(7):487-492
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the genetic association of complement factor B (CFB)gene polymorphisms with the susceptibility and prognosis of IgA nephropathy (IgAN).Methods Four hundreds and sixty-three Northern Han Chinese patients with IgAN and two hundreds and ninty-six geographically and ethnic matched healthy volunteers were recruited.Peripheral blood was collected from recruited individuals for DNA extracting.After amplified by plymerase chain reaction (PCR),genotyping of the four single nucleotide polymorphisms (SNPs) in CFB gene,which were rs4151667,rs12614,rs641153 and rs117314762,were performed by sequencing.Differences of allele and genotype frequencies were analyzed between IgAN patients and healthy controls.Moreover,the association between these SNPs and disease clinical manifestation,pathological features and long term renal outcome in IgAN patients were further analyzed.Results The G allele and GG genotype frequencies of rs117314762 in CFB gene were significantly higher in IgAN patients than that in healthy controls.No difference in allele and genotype frequencies of rs4151667,rs12614,rs641153 between IgAN patients and healthy controls was observed.Furthermore,no association was found between these SNPs in CFB gene and clinical manifestation,pathological features and long term renal outcome of IgAN.Conclusion Association between rs117314762 in CFB gene and IgAN susceptibility suggests that there may be functional variants in CFB gene or its linked genetic region,which needs further exploration.
