SOX1 and tumor

VernacularTitle:SOX1与肿瘤
Author: Jialiang ZHANG ; Zhong GUAN
Publication Type:Journal Article
Keywords: Neoplasms; SOX1 protein
From: Journal of International Oncology 2013;40(8):566-569
CountryChina
Language:Chinese
Abstract: SOX1,a member of the SOX transcript factor super family,has been demonstrated having the functions of regulating the development of human embryonic neural system and crystalline lens,and the additional function of SOX1 in tumors are attracting more and more attention as well.It is reported in resent years that SOX1 is detected lowly expressed in many kinds of tumor issues,which owns to the methylation of SOX1.SOX1 can also regulate the abilities of tumors on proliferation,invasion and migration.Besides,SOX1 may play a crucial role in regulation of the differentiation of cancer stem cells.Further research of SOX1 and its function among related pathways may contribute to seeking for new therapies for tumor treatment.