FHIT gene and tumor
10.3760/cma.j.issn.1673-422X.2013.08.001
- VernacularTitle:FHIT基因与肿瘤
- Author:
Na LI
;
Xiuhong JIA
- Publication Type:Journal Article
- Keywords:
Neoplasms;
Apoptosis;
Fragile histidine triad
- From:
Journal of International Oncology
2013;40(8):563-566
- CountryChina
- Language:Chinese
-
Abstract:
The human fragile histidine triad (FHIT) gene is a tumor suppressor gene,which is located at chromosome region 3p14.2.The fragile site FRA3B of the FHIT gene is the most unstable site.FHIT can promote apoptosis,and inhibit cell proliferation and tumorigenesis.High methylation status,loss of the various sections of the FHIT gene,changes of the fragile site FRA3B and abnormalities of FHIT transcripts can result in gene afunction,and then promote the development and progression of various types of cancers.Transfecting wild-type FHIT into tumor cells with low or lacking endogenous FHIT expression can induce apoptosis.The combined treatment with other genes may provide a new insight for the treatment of tumors.
