Study on modification and biocompatibility of coated medical polycarbonate

VernacularTitle:医用聚碳酸酯的涂层修饰及生物相容性研究
Author: Dawei DUAN ; Haibin LU ; Tong LI ; Meili YU ; Xiaomin HU ; Wenqing GAO
Publication Type:Journal Article
Keywords: Low molecular weight heparin; Oxidation sodium alginate; Polycarbonate; Biocompatibility
From: International Journal of Biomedical Engineering 2013;36(3):151-155
CountryChina
Language:Chinese
Abstract: Objective To prepare and evaluate the biocompatibility of polycarbonate coated with low molecular weight heparin (LMWH) and partial oxidation sodium alginate(OSA).Methods Coating material was prepared by means of chemical graft-modification and the feature of the material was determined with infrared spectrum and the stablity of the coating in fluid was examined.Biocompatibility was evaluated by contact angle and in-vitro tests including protein adhesion,platelet adhesion and caugulation.Results LMWH or OSA was tightly combined with polycarbonate.After being coated,the contact angle,albumin and fibrinogen adhering to materials were decrease (P＜0.05).The anticoagulant activity was notably promoted by coating.Compared with LMWH coated material,the contact angle,albumin and fibrinogen adhering were decreased significantly,but the improvement of anticaugulation was limited(P＜0.05).Conclusion Chemical graft-modification LMWH or OSA can be applied to polycarbonate.The biocompatibility of the coated materials was significantly promoted.