Clinical research of endocrine resistance in breast cancer
10.3760/cma.j.issn.1673-422X.2013.07.010
- VernacularTitle:乳腺癌内分泌耐药的临床研究进展
- Author:
Weibing LI
;
Qini XU
- Publication Type:Journal Article
- Keywords:
Breast neoplasms;
Receptors,estrogen;
Endocrine therapy
- From:
Journal of International Oncology
2013;40(7):509-511
- CountryChina
- Language:Chinese
-
Abstract:
Endocrine therapy is the most important systemic therapy for hormone receptor positive breast cancer.However,intrinsic or acquired resistance to endocrine therapy is a challenge currently.Crosstalk between estrogen receptor pathway and other pathway is considered to be one of the underlying mechanisms.Progress has been made in reversing resistance by blocking signaling through pathways such as the phosphoinositide 3-kinasesprotein kinase B-mammalian target of rapamycin and epidermal growth factor receptor pathway.
