Effect of pulmonary surfactant treatment on oxygenation in neonates with acute respiratory distress syndrome
10.3969/j.issn.1000-3606.2013.09.003
- VernacularTitle:肺泡表面活性物质对新生儿急性呼吸窘迫综合征氧合功能的影响
- Author:
Ming CHANG
;
Hongyan LU
- Publication Type:Journal Article
- Keywords:
pulmonary surfactants;
respiratory distress syndrome;
oxygenation;
neonate
- From:
Journal of Clinical Pediatrics
2013;(9):809-811
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the effect of early pulmonary surfactant (PS) treatment on oxygenation in neonates with acute respiratory distress syndrome (ARDS). Methods Clinical data of neonates with ARDS were retrospectively analyzed. All neonates with ARDS were divided into control group and treatment group. Neonates in treatment group were given PS at a dose of 70-100 mg/kg through the endotracheal tube. Results Among 64 neonates with ARDS, 18 neonates in treatment group were treated with PS, while other interventions were same with 46 neonates in control group. The PaO2/FiO2 and ventilation efifciency index were statistically higher in treatment group than those in control group at 6 h, 12 h, 24 h and 48 h (P<0.05). The oxygenation index and respiratory index were statistically lower in treatment group than those in control group at the same time points (P<0.05). Compared with control group, the treatment group also had a signiifcantly shorter duration of assisted ventilation and oxygen treatment (P<0.05). Conclusions Early treatment with PS in neonates with ARDS could improve the pulmonary compliance and oxygenation, and reduce the duration of assisted ventilation and oxygen treatment, and thus yield better prognosis.
