The diagnostic value of soluble triggering receptor expressed on myeloid cells-1 and lipopolysaccharide binding protein in neonatal serious bacterial infections
10.3969/j.issn.1000-3606.2013.09.004
- VernacularTitle:可溶性髓样细胞触发受体1、脂多糖连接蛋白在新生儿严重细菌感染诊断中的价值
- Author:
Yan LIN
;
Ying XIONG
- Publication Type:Journal Article
- Keywords:
bacterial infection;
soluble triggering receptor expressed on myeloid cells-1;
lipopolysaccharide binding protein;
C-reactive protein;
newborn
- From:
Journal of Clinical Pediatrics
2013;(9):812-816
- CountryChina
- Language:Chinese
-
Abstract:
Objective To evaluate the accuracy of the soluble triggering receptor expressed on myeloid cells-1 (sTREM-1) and lipopolysaccharide binding protein (LBP) as diagnostic indices for neonatal serious bacterial infections (SBI). Methods A total of 171 newborns were enrolled in the study, and were classiifed into SBI group (including early-onset and late-onset), non-SBI group according to clinical manifestations, laboratory examinations and the time of disease onset. Serum sTREM-1, LBP and C-reactive protein (CRP) levels were measured. Receiver operator characteristic curve (ROC) was drawn, and the area under curve (AUC) was calculated. Each index was evaluated for the diagnostic value of neonatal SBI. Results The sTREM-1 and LBP levels were signiifcantly higher in SBI group than those in non-SBI group (P=0.000). The AUC of ROC for sTREM-1, LBP and CRP in early-onset SBI was 0.888, 0.839 and 0.706, respectively. The AUC of ROC for sTREM-1, LBP and CRP in late-onset SBI was 0.860, 0.865 and 0.705, respectively. Conclusions Both sTREM-1 and LBP are useful for the diag-nosis of neonatal SBI.
