hsa-miR-1908 target genes prediction and bioinformatics analysis
10.3969/j.issn.1000-3606.2013.09.006
- VernacularTitle:hsa-miR-1908靶基因预测及生物信息学分析
- Author:
Lei YANG
;
Chenbo JI
;
Chunmei SHI
;
Ling CHEN
;
Lingxia PANG
;
Li XIA
;
Xirong GUO
;
Yuhui NI
- Publication Type:Journal Article
- Keywords:
hsa-miR-1908;
miRNA;
bioinformatics analysis;
human preadipocytes;
obesity
- From:
Journal of Clinical Pediatrics
2013;(9):820-824
- CountryChina
- Language:Chinese
-
Abstract:
Objective To predict the biological process and signaling pathways in which hsa-miR-1908 might be in-volved by a series of bioinformatics analysis, so as to lay foundations and provide theoretical basis for the further studies of hsa-miR-1908 biological function in human preadipocytes. Methods The sequence of hsa-miR-1908 was acquired from miR-Base database, and target genes of hsa-miR-1908 were predicted by miRanda, and then the intersection of the results and the results of gene-chip as gene set were further analyzed by gene ontology and pathway enrichment. Results The hsa-miR-1908 had some conserved property among different species. The functions of the target genes were enriched in Wnt receptor signal-ing pathway through beta-catenin, cell cycle, cell apeptosis and other biological processes. The GnRH signaling, MAPK sig-naling, insulin signaling, cell cycle signal transduction pathways and signaling pathway in pancreatic cancer were signiifcantly enriched. Conclusions The target genes set of hsa-miR-1908 were enriched in multiple biological process which are related with the obesity. This study provides guidance for the further study in human preadipocytes.
