Study on the levels of tumor necrosis factor-αand anti-ds-DNA antibody in children with systemic lupus erythe-matosus
10.3969/j.issn.1000-3606.2013.09.008
- VernacularTitle:系统性红斑狼疮患儿肿瘤坏死因子-α、抗ds-DNA抗体水平变化
- Author:
Dan HU
;
Yang LIU
;
Yanling LIU
- Publication Type:Journal Article
- Keywords:
systemic lupus erythematosus;
lupus nephritis;
tumor necrosis factor-α;
anti-ds-DNA antibody
- From:
Journal of Clinical Pediatrics
2013;(9):830-832
- CountryChina
- Language:Chinese
-
Abstract:
Objectives To investigate the changes and signiifcance of serum tumor necrosis factor-α(TNF-α) and anti-ds-DNA antibody in systemic lupus erythematosus (SLE) and lupus nephritis (LN) in children. Methods Sixty-seven children with SLE among whom 52 children had LN were selected and 30 healthy children were selected as normal controls. The level of serum TNF-αwas measured by enzyme-linked immunosorbent assay, and the anti-ds-DNA antibody level was measured by radioimmunoassay. Results The serum levels of TNF-αand anti-ds-DNA antibody were signiifcantly higher in children with SLE or LN than those in healthy controls (P all<0.01). Furthermore, the serum levels of TNF-αand anti-ds-DNA antibody were signiifcantly higher in active phase than in stationary phase of SLE and LN (P all<0.01). The serum TNF-αlevel was positively correlated with SLE disease activity index score and serum anti-ds-DNA level in 67 SLE patients (P<0.05). Conclu-sions The serum levels of TNF-αand anti-ds-DNA antibody were increased in children with SLE and LN and were positively correlated with disease activity.
