Multidrug resistance genes and related drug resistance proteins in cancer
10.3760/cma.j.issn.1673-422X.2013.07.005
- VernacularTitle:多药耐药基因及相关耐药蛋白在肿瘤中的研究进展
- Author:
Songjun SHAO
;
Xiangning ZHANG
;
Peichun HUANG
- Publication Type:Journal Article
- Keywords:
Drug resistance,neoplasms;
Multidrug resistance-associated proteins;
Cell cycle;
Neoplastic stem cells
- From:
Journal of International Oncology
2013;40(7):494-497
- CountryChina
- Language:Chinese
-
Abstract:
Chemotherapy is one of the most important methods of cancer treatment.However,multidrug resistance (MDR) has been the main factors affecting their efficacies.Recent studies show that the amplification of MDR1 gene in tumor cells,the over expression of the related drug resistance protein and the cell cycle and apoptosis pathway in signal transduction are the main causes for the failure of chemotherapy.
