New treatment for sepsis:stem cell therapy
10.3969/j.issn.1672-7347.2013.07.017
- VernacularTitle:脓毒症治疗的新希望：干细胞疗法
- Author:
Shangping ZHAO
;
Mingshi YANG
- Publication Type:Journal Article
- Keywords:
mesenchymal stem cell;
sepsis;
inflammatory factor;
multiple organ dysfunction;
immune regulation
- From:
Journal of Central South University(Medical Sciences)
2013;38(7):754-760
- CountryChina
- Language:Chinese
-
Abstract:
Sepsis is the systemic inlfammatory response to infection and a major cause of mortality in critical patients. The severe disorder of immune system is the common pathophysiological changes in septic patients. Mesenchymal stem cells (MSCs) have shown great immunoloregulation properties in recent studies. It can increase the level of IL-10, an anti-inflammatory cytokine, promote the secretion of prostaglandin E2 (PGE2), indolamine 2,3-dioxygenase (IDO), and regulate the proliferation, differentiation and function of the immune cells such as mononuclear macrophage, t-lymphocytes, natural killer cells and so on. MSCs may provide new ideas for the treatment of sepsis.
