Effect of Danzhi Jiangtang Capsule Combined with Atorvastatin on Intima-media Thickness in Diabetes Patients without Hypertension
10.11842/wst.2013.05.018
- VernacularTitle:丹蛭降糖胶囊联合阿托伐他汀钙对糖尿病不伴有高血压病患者颈动脉内膜中层厚度的影响
- Author:
Zhaohui FANG
;
Jindong ZHAO
;
Jinping WANG
;
Yunfei NIU
;
Yiqiong SHU
;
Aihong YUAN
;
Qian WU
;
Qingyun FAN
;
Jian LIU
;
Taotao BAO
;
Yuan LUO
;
Ruimin LU
;
Chenglin GUO
;
Ting JIANG
;
Liqun CUI
;
Hui YANG
- Publication Type:Journal Article
- Keywords:
Danzhi Jiangtang Capsule;
atorvastatin;
diabetes patients without hypertension;
carotid artery intima-media thickness
- From:
World Science and Technology-Modernization of Traditional Chinese Medicine
2013;(5):884-890
- CountryChina
- Language:Chinese
-
Abstract:
This study was aimed to observe the curative effect and safety of Danzhi Jiangtang Capsule ( DJC ) combined with atorvastatin on carotid artery intima-media thickness (IMT) in diabetes patients without hyper-tension . A total of 196 diabetes patients without hypertension with incrassate carotid artery IMT were randomly divided into the control group ( 98 cases ) and the treatment group ( 98 cases ) . The conventional diabetes thera-py was given to both groups . The atorvastatin of 20 mg/night was given to the control group . And the atorvas-tatin 20 mg/night added with DJC 9 . 0 g/night were given to the treatment group . The treatment course was
12 months . Carotid artery IMT , carotid atherosclerotic plaque area , FPG , FIns , HOMA-IR , HbA1c , blood lipids , hepatorenal function and etc . were examined before and after the treatment respectively . The results showed that there was a significant positive correlation between carotid artery IMT and FIns , HOMA-IR , HbAlc , LDL-C . After 12-month treatment , the total effectiveness is 85 . 87% in the treatment group . And there was significant difference compared with the control group ( P < 0 . 05 ) . The levels of FPG , FIns , HOMA-IR , HbAlc of the treatment group had no difference compared with the control group . Compared with the control group, TC and LDL-C of the treatment group was obviously decreased (P < 0.05). And HDL-C was significantly increased ( P < 0 . 05 ) . The carotid artery IMT of the treatment group decreased from ( 0 . 11 ±0 . 01 ) cm to ( 0 . 08 ± 0 . 01 ) cm . And compared with the control group , there was statistical significance ( P <0 . 05 ) . The carotid atherosclerotic plaque area of 58 cases in the treatment group decreased from ( 0 . 37 ±0.56) cm2 to (0.21 ± 0.25) cm2. However, there was no statistical significance compared to the control group. There were 5 adverse events in the control group and 9 adverse events in the treatment group . And there was no difference between two groups. It was concluded that DJC combined with atorvastatin can regulate lipid metabolism and reduce carotid artery IMT .
