Effect of Danzhi Jiangtang Capsule on NF-κB and Urinary Albumin Excretion Rate in Early Diabetic Nephropathy Patients
10.11842/wst.2013.05.019
- VernacularTitle:丹蛭降糖胶囊对早期糖尿病肾病患者血NF-κB和尿白蛋白排泄率的影响
- Author:
Zhaohui FANG
;
Senhua CHENG
;
Qian WU
- Publication Type:Journal Article
- Keywords:
Danzhi Jiangtang Capsule;
early diabetic nephropathy;
urinary albumin excretion rate;
NF-κB
- From:
World Science and Technology-Modernization of Traditional Chinese Medicine
2013;(5):891-895
- CountryChina
- Language:Chinese
-
Abstract:
This study was aimed to observe the effect of Danzhi Jiangtang Capsule ( DJC ) on NF-κB in the peripheral blood mononuclear cell , and inflammation indices such as serum MCP-1 , TGF-β1 and urinary albu-min excretion rate ( UAER ) in early diabetic nephropathy ( EDN ) , in order to discuss the possible mechanism of DJC on anti-inflammatory and renal protection effect of EDN. A total of 72 EDN patients which met the in-clusion criteria after the start-up stage were taken as research objects . They were randomly divided into the control group and the treatment group. The western comprehensive treatment plan was given to both groups. In the treatment group, DJC was added. And the treatment course was 8 weeks. Changes of MCP-1, NF-κB, TGF-β1 and UAER were observed before and after the treatment . The results showed that MCP-1 , NF-κB and TGF-β1 had significant positive correlation with UAER ( P < 0 . 05 , or P < 0 . 01 ) . Compared to pre-treat-
ment , the levels of MCP-1 , NF-κB , TGF-β1 and UAER in the control group and treatment group after treat-ment were significantly declined ( P < 0 . 05 ) . Compared with the control group , after treatment , the levels of MCP-1 , NF-κB , TGF-β1 and UAER of the treatment group were obviously reduced ( P < 0 . 05 , or P <0 . 01 ) . It was concluded that DJC can reduce the UAER , delay the renal injury , and downregulate levels of MCP-1, NF-κB and TGF-β1, block the expression of inflammatory mediators, inhibit inflammatory reaction and improve microinflammatory state of EDN. This may be one of the important mechanisms in the protection of renal function .
