Clinical analysis of prenatal diagnosis of choledochal cyst in 37 infants

Jimeng HU; Qing Liu; Yeming WU; Ying Zhou; Jun Wang; Weihua Pan

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Clinical analysis of prenatal diagnosis of choledochal cyst in 37 infants

VernacularTitle:产前诊断先天性胆总管囊肿37例临床分析
Author: Jimeng HU ; Qing LIU ; Yeming WU ; Ying ZHOU ; Jun WANG ; Weihua PAN
Publication Type:Journal Article
Keywords: choledochal cyst; prenatal diagnosis; treatment
From: Journal of Clinical Pediatrics 2013;(9):858-861
CountryChina
Language:Chinese
Abstract: Objectives To explore the clinical intervention of prenatal diagnosed congenital choledochal cyst in infants. Methods 37 infants with prenatally diagnosed congenital choledochal cyst from September 2006 to February 2013 were di-vided into early (0-3 month) operation group (Group A, n=20) and late (>3 month) operation group (Group B, n=17) according to the timing of surgery. The clinical characteristics, the preoperative and postoperative liver function, postoperative com-plications and pathological examination of liver biopsy were retrospectively analyzed. Results Five infants in group A and 2 infants in group B became jaundiced after birth. No statistical difference was found in alanine aminotransferase (ALT) and aspartate aminotransferase (AST) between two groups (P>0.05). Preoperative and postoperative levels of total bilirubin (TBIL) and direct bilirubin (DBIL) in group A were signiifcantly higher than those in group B (P<0.05). Two cases had anastomotic stricture and one case had bile leakage in group A while no postoperative complication was found in group B. Liver biopsy re-sults showed that there were 11 cases of biliary cirrhosis, including 4 cases in group A (36.36%) and 7 cases (63.64%) in group B, but no statistical difference in incidence of cirrhosis between two groups (P=0.160). Conclusions Infants with prenatally diagnosed congenital choledochal cyst should be closely observed. Once jaundice, clay-coledstool, increased ALT and AST, fast growing enlarged cysts were found, infants should be surgically treated as soon as possible to reduce liver damage and the incidence of liver cirrhosis.