Metabolic Network Construction and Feature Analysis of Hypertension with Syndrome of Ascendant Hyperactivity of Liver Yang
10.11842/wst.2013.05.029
- VernacularTitle:高血压病肝阳上亢证代谢网络构建及特征分析
- Author:
Haiqiang JIANG
;
Yunlun LI
- Publication Type:Journal Article
- Keywords:
Metabolic network;
hypertension with syndrome of ascendant hyperactivity of liver yang;
metabolism node;
biological nature
- From:
World Science and Technology-Modernization of Traditional Chinese Medicine
2013;(5):942-946
- CountryChina
- Language:Chinese
-
Abstract:
This study was aimed to build metabolic network of hypertension with syndrome of ascendant hyper-activity of liver yang by associating metabolic biomarkers in order to reveal the biological nature of hyperten-sion from the whole view . According to the diagnostic criteria of hypertension with syndrome of ascendant hy-peractivity of liver yang, typical cases were selected and healthy volunteers were enrolled as comparison . Metabolic biomarkers were revealed by metabolomics methods. The metabolic pathways of biomarkers were re-vealed with the KEGG database . The metabolic pathways were connected to establish the metabolic network . Key targets were identified using metabolism node analysis . The results showed that compared with healthy vol-unteers , the metabolic network of hypertension with syndrome of ascendant hyperactivity of liver yang had sig-nificant changes . Norepinephrine , hexanose and arachidonic acid are key network nodes . It was concluded that the metabolic network according to metabolic biomarkers has the advantage in the study on changes of the body under complicated conditions . The study provided a scientific basis for the understanding of biological na-ture of hypertension with syndrome of ascendant hyperactivity of liver yang.
