Clinical Research on Efficacy of Bushen Huoxue Kaiqiao Prescription in the Treatment of 30 Diabetes-induced Vascular Mild Cognitive Impairment Cases
10.11842/wst.2013.05.051
- VernacularTitle:补肾活血开窍方治疗糖尿病所致血管性轻度认知功能障碍30例临床研究
- Author:
Shuoguo JIN
;
Jingtao LANG
;
Xuhong YANG
;
Huan ZHAO
;
Min SHI
;
Weiyin CHEN
;
Honghui SUN
;
Ningjing RAN
;
Getong MU
;
Hanbing CHEN
;
Dongdong YANG
- Publication Type:Journal Article
- Keywords:
Bushen Huoxue Kaiqiao prescription;
vascular mild cognitive impairment;
nimodipine;
clinical trial
- From:
World Science and Technology-Modernization of Traditional Chinese Medicine
2013;(5):1051-1055
- CountryChina
- Language:Chinese
-
Abstract:
This study was aimed to observe clinical efficacy of Bushen Huoxue Kaiqiao (BSHXKQ) treatment of diabetes-induced vascular mild cognitive impairment . A total of 30 cases of diabetes-induced vascular mild cognitive impairment were randomly divided into the treatment group ( 15 cases ) and the control group ( 15 cas-es). The treatment group received free-fried BSHXKQ prescription (Cistanche 10 g, Shichangpu 5 g, Sanqi 2 . 5 g ) for treatment 3 times a day , and in combination of 30 mg of nimodipine , 3 times a day . In the con-trol group , 30 mg of nimodipine was orally administrated 3 times a day . The treatment was continued for 6 months. Clinical Dementia Rating (CDR), Activity of Daily Living Scale (ADL), Montreal Cognitive Assessment Beijing Edition ( MoCA ) and TCM Syndrome Score were used in the evaluation before and after the treatment . The results showed that the rate of progress was in both groups after treatment . In the treatment group , the rate was 86 . 70%, and in the control group the rate was 33 . 33%. The total effective rate in the treatment group was superior to the control group ( P < 0 . 05 ) . There were statistical significances in the MoCa Scale , ADL Scale and TCM Syndrome Score before and after treatment in each group ( P < 0 . 05 ) . The treatment ef-fect in the treatment group was superior to the control group ( P < 0 . 05 ) . There was no statistical significance in the incidence of adverse events in both groups . It was concluded that the effect of BSHXKQ prescription in the treatment of diabetes-induced vascular mild cognitive impairment was superior to nimodipine in improving activities of daily living , cognitive function , degree of dementia and TCM syndrome score . There was no differ-ence in the incidence of adverse events compared with nimodipine .
