Relationship between AECA and systemic vasculitis
10.3969/j.issn.1000-3606.2013.09.025
- VernacularTitle:抗内皮细胞抗体与系统性血管炎关系的研究进展
- Author:
Shaomin REN
;
Baiyu CHEN
- Publication Type:Journal Article
- Keywords:
endothelial cell;
anti-endothelial cell antibodies;
systemic vasculitis;
autoimmune diseases
- From:
Journal of Clinical Pediatrics
2013;(9):891-893
- CountryChina
- Language:Chinese
-
Abstract:
Anti-endothelial cell antibodies (AECA) are heterogeneous autoimmune antibodies, which target at a group of antigens expressed in endothelial cells. In 1971, AECA was reported by Lindquist and Osterland for the first time. Since then, an increasing number of researches have showed that AECA exists and plays potential pathogenic role in the immune or inlfammation-related diseases, especially in systemic vasculitis. AECA may be a useful sera marker for the diagnosis and prognosis judgment of related autoimmune diseases. In this review, we summarize the recent progress on the relationship between AECA and systemic vasculitis.
