Possible Roles of UL112-113 Proteins in Human Cytomegalovirus DNA Replication.
10.4167/jbv.2012.42.2.162
- Author:
Young Eui KIM
1
;
Jin Hyun AHN
Author Information
1. Department of Molecular Cell Biology, Samsung Biomedical Research Institute, Sungkyunkwan University School of Medicine, Suwon, Korea. jahn@skku.edu
- Publication Type:Letter
- Keywords:
HCMV;
DNA replication;
UL112-113
- MeSH:
Cytomegalovirus;
DNA;
DNA Replication;
DNA, Viral;
Humans;
Proteins;
Replication Origin;
Viral Proteins
- From:Journal of Bacteriology and Virology
2012;42(2):162-168
- CountryRepublic of Korea
- Language:Korean
-
Abstract:
DNA replication of human cytomegalovirus (HCMV) is a highly regulated process that requires specific interactions between cis-acting lytic origin of replication (oriLyt) and trans-acting viral proteins. Formation of the replication initiation complex is also regulated by specific interactions among viral replication proteins. HCMV replication proteins include origin-binding proteins, core proteins that work in replication forks, and regulatory proteins that modulate host cell functions. This letter describes intriguing questions regarding how HCMV origin-binding proteins interact with oriLyt to initiate DNA replication and how the regulatory UL112-113 proteins, which are found only in beta-herpesviruses, function to promote viral DNA replication.
