Caspase-11, the Main Executioner in Non-canonical Inflammasome.
10.4167/jbv.2012.42.2.169
- Author:
Zahid MANZOOR
1
;
Young Sang KOH
Author Information
1. Department of Microbiology and Immunology, Jeju National University School of Medicine, Jeju, Korea. yskoh7@jejunu.ac.kr
- Publication Type:Letter
- Keywords:
Caspase-11;
Caspase-1;
Sepsis;
Inflammasome
- MeSH:
Bacterial Infections;
Cholera Toxin;
Citrobacter rodentium;
Criminals;
Escherichia coli;
Humans;
Immunity, Innate;
Sepsis;
Vibrio cholerae
- From:Journal of Bacteriology and Virology
2012;42(2):169-171
- CountryRepublic of Korea
- Language:English
-
Abstract:
Murine caspase-11 is orthologus to human caspase-4 and caspase-5, and is required for the response to cholera toxin B and infection with Escherichia coli, Citrobacter rodentium or Vibrio cholerae. Caspase-11 rather than caspase-1 is the main offender involved in sepsis. Hence, caspase-11 plays an essential pro-inflammatory role in innate immune response to bacterial infections.
